Your Virtual Green Tea House
This is the green tea home page link textimage spaceremail us for more informationimage spacergreentelovers site mapimage spacershopping cart
green tea history
green tea classification
green tea links
Try Our Quickshop Menu
FAIL (the browser should render some flash content, not this).

green tea health query
Plus a discount coupon for new customers to try our tea
Green Tea & Cancer - Read what noted Oncologist Dr. Mitchell Gaynor's has to say about green tea. Select from our updated articles database for specific cancers:

Skin Cancer: General


Date: 01-01-2010
The main polyphenol in green tea is epigallocatechin gallate (EGCG). Scientific studies suggest that EGCG and green tea polyphenols have anti-inflammatory and anticancer properties that may help prevent the onset and growth of skin tumors.

Tea Extracts Help Treat Damaged Skin In Cancer Patients


Date: 12-01-2006
ScienceDaily (Dec. 1, 2006) — Tea extracts work as an effective treatment for patients who suffer from damaged skin following radiation treatment for cancer. Researchers show that this might partly be due to the anti-inflammatory properties of tea. In a study published in the open access journal BMC Medicine, researchers show that tea acts at the cellular level, by inhibiting inflammatory pathways, to reduce inflammation. They also show that tea extracts reduce the duration of radiation-induced skin damage by up to 10 days in patients who received radiation treatment. Frank Pajonk, from the University of California in Los Angeles, USA, and colleagues from the University of Freiburg, Germany, studied the effects of green tea and black tea extracts on patients who had been treated with radiotherapy, which can damage the skin. The authors then analysed the effects of the same tea extracts on human and mouse white blood cells in culture. Pajonk et al. find that tea extracts reduce the duration of skin toxicity following radiotherapy by 5 to 10 days. Green tea extracts are more effective than black tea extracts in some patients. Pajonk et al. also show that tea extracts reduce the release of pro-inflammatory cytokines, such as IL-1beta, IL-6, IL-8, TNFalpha and PGE2, in human white blood cells in culture, with green tea having higher anti-inflammatory properties than black tea. Both black tea and green tea inhibit one major inflammatory pathway in mouse white blood cells. Pajonk et al. add that tea's high content of polyphenols is likely to be responsible for its high anti-inflammatory activity, but that other pathways are probably involved in its clinical effectiveness.

Green Tea & Skin Cancer - Cima Labs


Date: 01-01-2003
Skin cancer, and the protective effects of catechins on the skin, have been studied extensively. Ultraviolet radiation is known to cause inflammation and immune, making the skin more susceptible to cancer. High doses of epigallocatechin gallate and other catechins are particularly effective in preventing inflammation and skin cancer, especially if delivered in the topical form. Topical epigallocatechin gallate was found to reduce the release of inflammatory prostaglandin's (the E2 series), which play a crucial role in generating free radicals and promoting tumor growth. Due to its antimutagenic and antitumor activities, green tea is a promising candidate for use in topical formulations for skin cancer prevention. Epigallocatechin gallate (EGCG) is a potent polyphenolic antioxidant extracted from green tea. Cima Labs did a study to determine the influence of several factors on the stability of EGCG in solution to obtain information that would facilitate the subsequent development of topical formulations. A second objective was to determine the stability of EGCG in various solvents in the presence and absence of different antioxidants. It was concluded that glycerin-based vehicles are suitable for stabilizing EGCG as a topical formula.

Green Tea & Skin Cancer - U.S.C. Study


Date: 01-01-2003
In a study done by USC/Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, 10 separate experiments, mice with established chemically induced or UV light-induced skin papillomas were treated continuously with green tea in the drinking water or with i.p. injections of a green tea polyphenol fraction or (-)-epigallocatechin gallate three times a week for 4-10 weeks. Partial tumor regression or > 90% inhibition of tumor growth, as measured by changes in tumor volume per mouse, was observed in 5 experiments, and marked inhibition of tumor growth (46-89%) was observed in 5 additional experiments. Treatment of the mice with green tea or green tea constituents had an inhibitory effect on body weight increases in several but not all of the studies. Examination of the data from all ten experiments revealed that complete tumor regression occurred in 14 of 346 papilloma-bearing mice (4%) that were treated with green tea in the drinking water or with i.p. injections of green tea constituents, whereas none of the 220 papilloma-bearing control mice treated with only vehicle exhibited complete tumor regression. These observations indicate that oral administration of green tea, i.p. administration of a green tea polyphenol fraction, or i.p. administration of (-)-epigallocatechin gallate inhibited the growth and/or caused the regression of established experimentally induced skin papillomas. The main polyphenol in green tea is epigallocatechin gallate (EGCG). Scientific studies suggest that EGCG and green tea polyphenols have anti-inflammatory and anti-cancer properties that may help prevent the onset and growth of skin tumors.
References: Life Extension Magazine and other studies added.

Asano Y, Okamura S et al. Effect of epigallocatechin gallate on leukemic blastcells from patients with acute myeloblastic leukemia. Life Sci 1997; 60:135-42 Berger SJ, et al. Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells. Biochem Biophys Res Commun 2001;288:101-5.
Challa A et al. Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. Carcinogenesis 1997; 10:2023-26
Chen ZP, et al. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Lett 1998; 129:173-79
Chung FL et al. Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: Caffeine as an important constituent. Cancer Res 1998;58:4096-4101
Deng ZY, Tao BY, et al. Effect of green tea and black tea on blood glucose, triglycerides, and antioxidants in aged rats. J Agricult Food Chem 1998;46:3875-78
Francheschi S et al. Influence of food groups and food diversity on breast cancer risk in Italy. Int J Cancer 1995; 63:785-89
Goodwin Sarah Federation of American Societies for Experimental Biology 18-Apr-2004
Hamilton-Miller JM. Anti-cariogenic properties of tea (Camellia sinensis). J Med Microbiol 2001;50:299-302
Hara Y. Influence of tea catechins on the digestive tract. J Cel Biochem 1997; Suppl 27: 52-58
Hibasami H et al. Induction of apoptosis in human stomach cancer cells by green tea catechins. Oncol Repetition 1998; 5:527-29
Hirose M et al. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with MDBA. Cancer Lett 1994; 83:149-56
Hong J, et al. Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem Pharmacol 2001;62:1175-83
Hoshiyama Y, et al. A prospective study of stomach cancer death in relation to green tea consumption in Japan. Br J Cancer 2002;87:309-13
Huang MT, et al. Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea. Cancer Res 1997;57:2623-9
Hsu SD, et al. Chemoprevention of oral cancer by green tea. Gen Dent 2002;50:140-6
Inoue M, Tajima K, et al. Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. Cancer Causes Control 1998;9:209-16
Ito Y et al. Chromosome aberrations induced by aflatoxin B1 in rat bone marrow cells in vivo and their suppression by green tea. Mutat Res 1989; 222:253-61
Jian L, Xie LP, Lee AH, Binns, CW Protective Effect Of Green Tea Against Prostate Cancer: A Case Control Study In Southeast China Int J Cancer:108. 130-135 (2004)
Katiyar SK, Mukhtar H. Tea antioxidants in cancer chemoprevention. J Cell Biochem Suppl 1997; 27:59-67
Katiyar SK et al. Polyphenolic antioxidant epigallocatechin gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem Photobiol 1999; 69:148-53
Khafif A; Schantz SP, et al. Quantitation of chemopreventive synergism between epigallocatechin gallate and curcumin in normal, premalignant, and malignant oral epithelial cells. Carcinogenesis 1998;19:419-24
Kinjo J, et al. Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells. Biol Pharm Bull 2002;25:1238-40
Komori A, Yasunami J, et al. Anticarcinogenic activity of green tea polyphenols. Jpn J Clin Oncol 1993; 23:186-90
Kuroda Y, Hara Y. Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutat Res 1999; 436:69-97
Larsson, Susanna, Wolk Alicja, Karolinksa Institute. A relationship between the amounts of tea a middle-age woman drinks and her risk for ovarian cancer. Archives of Internal Medicine. Dec. 12 issue.
Lean ME et al. Dietary flavonols protect diabetic human lymphocytes against oxidative damage to DNA. Diabetes 1999; 48:176-81
Lee IP et al. Chemopreventive effects of green tea against cigarette smoke-induced mutations in humans. J Cell Biochem 1997; Suppl 27:68-75
Lee YK, et al. VEGF Receptor Phosphorylation Status and Apoptosis is Modulated by a Green Tea Component, Epigallocatechin-3-gallate (EGCG) in B cell Chronic Lymphocytic Leukemia. Blood 2004;104(3):788-94
Liao S, Hipakka RA. Selective inhibition of steroid 5-alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate. Biochem Biophys Res Commun 1995;214:833-38
Liao S, Umekita Y et al. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett 1995; 96:239-43
Lin YL, Cheng CY, et al. Hypolipidemic effect of green tea leaves through induction of antioxidant and phase II enzymes including superoxide dismutase, catalase, and glutathione S-transferase in rats. J Agricult Food Chem 1998;46:1893-99
Lu LH, Lee SS, Huang HC. Epigallocatechin suppression of proliferation of vascular smooth muscle cells: correlation with c-jun and JNK. Brit J Pharmacol 1998;124:1227-37
McCarty MF. Polyphenol-mediated inhibition of AP-1 transactivating activity may slow cancer growth by impeding angiogenesis and tumor invasiveness. Med Hypoth 1998; 50:511-14
Morre D, Morre DJ. Findings on epigallocatechin gallate and tNOX inhibition presented at the 38th annual meeting of the American Society for Cell Biology; summary available at http//www.uns.purdue.edu
Naasani I et al. Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem Biophys Res Commun 1998; 249:391-96
Nagata C et al. Associations of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer 1998; 30:21-24
Nakachi K, Suemasu K, et al. Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J Cancer Res 1998;89:254-61
Oguri A et al. Inhibitory effects of antioxidants on formation of heterocyclic amines. Mutat Res 1998; 402:237-45
Otsuka T, Ogo T, et al. Growth inhibition of leukemic cells by epigallocatechin gallate, the main constituent of green tea. Life Sciences 1998; 63:1397-1403
Parshad R, Sanford RR, et al. Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells. Anticancer Res 1998;18:3263-66
Pashka AG et al. Induction of apoptosis in prostate cancer cell lines by the green tea component, epigallocatechin gallate. Cancer Lett 1998;130:1-7
Pisters KM, et al. Phase I trial of oral green tea extract in adult patients with solid tumors. J Clin Oncol 2001;19:1830-8.
Proniuk S, et al. Preformulation study of epigallocatechin gallate, a promising antioxidant for topical skin cancer prevention. J Pharm Sci 2002;91:111-6
Quin G et al. Inhibition of aflatoxin B1-induced initiation of hepatocarcinogenesis in the rat by green tea. Cancer Lett 1997; 112:149-54
Reuters. Green tea blocks angiogenesis. Internet Health News, 3-31-1999
Sai I, Kai S et al. Protective effects of green tea on hepatotoxicity, oxidative DNA damage and cell proliferation in the rat liver, induced by repeated oral administration of 2-nitropropane. Food Chem Toxicol 1998; 6:1043
Sartippour MR, et al. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr 2002;132:2307-11.
Sazuka M, Imazawa H, et al. Inhibition of collagenases from mouse lung carcinoma cells by green tea catechins and black tea theaflavins. Biosci Biotechnol Biochem 1997; 61:1504-06
Smith DM, et al. Green tea polyphenol epigallocatechin inhibits DNA replication and consequently induces leukemia cell apoptosis. Int J Mol Med 2001;7:645-52
Suganuma M, Okabe S, et al. Synergistic effects of epigallocatechin gallate with epicatechin, sunlilndac, or tamoxifen on cancer-preventive activity in the human lung cancer cell line PC-9. Cancer Res 1999;59:44-7
Sugiyama T, Sadzuka Y. Combination of theanine with doxorubicin inhibits hepatic metastasis of M5076 ovarian sarcoma. Clin Cancer Res 1999; 5:413-16
Sugiyama T, Sadzuka Y. Enhancing effects of green tea components on the antitumor activity of adriamycin against M5076 ovarian sarcoma. Cancer Lett 1998; 133:19-26
Sun CL, et al. Urinary tea polyphenols in relation to gastric and esophageal cancers: a prospective study of men in Shanghai, China. Carcinogenesis 2002;23:1497-503.
Tosetti F, Ferrari N, De Flora S. Angioprevention: angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J 2002;16:2-14
Tsubono Y, et al. Green tea and the risk of gastric cancer in Japan. N Engl J Med 2001;344:632-6
Valcic S et al. Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs 1996; 7:461-68
Wang ZY, et al. Inhibitory effect of green tea on the growth of established skin papillomas in mice. Cancer Res 1992;52:6657-65.
Yamane T, Nakatsni H et al. Inhibitory effects and toxicity of green tea polyphenols for gastrointestinal carcinogenesis. Cancer 1996;77(suppl):1662-67
Yan YS. Effect of Chinese tea extract on the immune function of mice bearing tumors and their antitumor activity. Chung Hua Yu Fang 1992; 26:5-7
Yang CS, et al. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev 1998;7:351-4.
Yang CS, et al. Prevention of carcinogenesis by tea polyphenols. Drug Metab Rev 2001;33:237-53
Yang CS, et al. Human salivary tea catechin levels and catechin esterase activities: implications in human cancer prevention studies. Cancer Epidemiol Biomarkers Prev 1999;8:83-9
Yang FJ et al. Green tea polyphenols block endotoxin-induced tumor necrosis factor alpha production and lethality in murine model. J Nutr 1998; 128:2334-40
Yang GY, Liao J, et al. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 1998; 19:611-16
Zhang, M, Binns, CW, Lee, A Tea Consumption and Ovarian Cancer Risk: A Case control Study in China. Cancer Epidemiol Biomarkers Prev (2002) 11:713-718.
Zhen Y et al. Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites. Chin Med Sci 1991; 6:1-5
Zhu BT, Taneja N et al. Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone. J Steroid Biochem Mol Biol 1998;64:207-15

Our tea and tea ware have a variety of certifications:

fair trade label
USDA Organic

ETP Ethical  Partnership
HACCP
ISO 14001

FDA
image spacer
Learn More about...
- Our Shipping/Return Policy
- Our Privacy Policy
- Our Environmental Impact
-
Testimonials/Newsletter
- Follow Us On facebook
twitter
-
Our SECURE shopping cart accepts multicurrency, credit cards & paypal.
image spacer


image spacer
image spacer
© 2005 Greentealovers.com -- info@greentealovers.com
850 Napoleon St., Woodmere, NY 11598 / Tel: 516-374-6538 (Phone/Fax)
Some images and information are courtesy of ITO EN, Inc.